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Life extension science, also known as anti-aging medicine, experimental gerontology, and biomedical gerontology, is the study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan. Some researchers in this area, and “life extensionists” or “longevists” (those who wish to achieve longer lives themselves), believe that future breakthroughs in tissue rejuvenation with stem cells, molecular repair, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition.
The sale of putative anti-aging products such as nutrition, physical fitness, skin care, hormone replacements, vitamins, supplements and herbs is a lucrative global industry, with the US market generating about $50 billion of revenue each year. Medical experts state that the use of such products has not been shown to affect the aging process, and many claims of anti-aging medicine advocates have been roundly criticized by medical experts, including the American Medical Association.
However, it has not been shown that the goal of indefinite human lifespans itself is necessarily unfeasible; some animals such as lobsters and certain jellyfish do not die of old age, and an award was offered to anyone who could prove life extensionist Aubrey de Grey’s hopes were ‘unworthy of learned debate’; nobody won the prize. Bioethicists question the ethical ramifications of life extension.
[hide] 1 Average and maximum lifespans
2 Current anti-aging strategies and issues 2.1 Diets and supplements
2.2 Hormone treatments 2.2.1 Insulin like growth factor (IGF-1) restriction
2.3 Scientific controversy regarding anti-aging nutritional supplementation and medicine
2.4 Ethics and politics of anti-aging nutritional supplementation and medicine
2.5 Consumer motivations for using anti-aging products
3 Proposed strategies of life extension 3.1 Nanotechnology
3.2 Cloning and body part replacement
3.4 Strategies for Engineered Negligible Senescence (SENS)
3.5 Genetic modification
3.6 Fooling genes
3.7 Reversal of informational entropy
4 History of life extension and the life extension movement
5 Ethics and politics of life extension
6 Aging as a disease
7 See also
9 Further reading 9.1 Books
9.2 Scientific journals
10 External links
 Average and maximum lifespans
Main article: Senescence
During the process of aging, an organism accumulates damage to macromolecules, its cells, its tissues and its organs. This accumulated damage is the result of oxidation damage to the cell contents caused by free radicals, though other things cause aging as well.
The longest a human has ever been proven to live is 122 years, the case of Jeanne Calment who was born in 1875 and died in 1997, whereas the maximum lifespan of a mouse, commonly used as a model in research on aging, is about four years. Genetic differences between humans and mice that may account for these different aging rates include efficiency of DNA repair, types and quantities of antioxidant enzymes, and different rates of free radical production. The most important and challenging factor remains the telomere limitation of each individual species.
Average lifespan in a population is lowered by infant and child mortality, which are frequently linked to infectious diseases or nutrition problems. Later in life, vulnerability to accidents and age-related chronic disease such as cancer or cardiovascular disease play an increasing role in mortality. Extension of expected lifespan can often be achieved by access to improved medical care, vaccinations, good diet, exercise and avoidance of hazards such as smoking.
Maximum lifespan is determined by the rate of aging for a species inherent in its genes and by environmental factors. One widely recognized method of extending maximum lifespan in organisms such as nematodes is calorie restriction. Another technique used evolutionary pressure such as breeding from only older members.
Theoretically, extension of maximum lifespan could be achieved by reducing the rate of aging damage, by periodic replacement of damaged tissues, or by molecular repair or rejuvenation of deteriorated cells and tissues and the enhancement of telomerase enzyme activity. Future research will be geared towards telomere repair strategies.
 Current anti-aging strategies and issues
See also: Ageing#Prevention and reversal
 Diets and supplements
Much life extension research focuses on nutrition—diets or supplements—as a means to extend lifespan, although few of these have been systematically tested for significant longevity effects. The many diets promoted by anti-aging advocates are often contradictory. A dietary pattern with some support from scientific research is caloric restriction.
The free-radical theory of aging suggests that antioxidant supplements, such as Vitamin C, Vitamin E, Q10, lipoic acid, carnosine, and N-acetylcysteine, might extend human life. However, combined evidence from several clinical trials suggest that β-Carotene supplements and high doses of Vitamin E increase mortality rates. Other substances proposed to extend lifespan include oxytocin, insulin, human chorionic gonadotropin (hCG), and erythropoietin (EPO). Resveratrol is a sirtuin stimulant that appears to extend lifespan in simple organisms such as nematodes and short-lived fish.
Some supplements, including the minerals selenium or zinc have been reported to extend the lifespan of rats and mice, though none have been proven to do so in humans, and significant toxic effects were observed. Metformin may also extend life span in mice.
There are many traditional herbs purportedly used to extend the health-span, including a Chinese tea called Jiaogulan (Gynostemma pentaphyllum), dubbed “China’s Immortality Herb.”  Ayurveda, the traditional Indian system of medicine, describes a class of longevity herbs called rasayanas, including Bacopa monnieri, Ocimum sanctum, Curcuma longa, Centella asiatica, Phyllanthus emblica, Withania somnifera and many others. Along with their Chinese counterparts (called superior or tonic herbs), Indian rasayanas demonstrate preliminary positive results in animal models.
 Hormone treatments
The anti-aging industry offers several hormone therapies. Some of these have been criticized for possible dangers to the patient and a lack of proven effect. For example, the American Medical Association has been critical of some anti-aging hormone therapies.
Even if some recent clinical studies have shown that low-dose growth hormone (GH) treatment for adults with GH deficiency changes the body composition by increasing muscle mass, decreasing fat mass, increasing bone density and muscle strength, improves cardiovascular parameters (i.e. decrease of LDL cholesterol), and affects the quality of life without significant side effects. The evidence for use of growth hormone as an anti-aging therapy is mixed and based on animal studies. An early study suggested that supplementation of mice with growth hormone increased average life expectancy. Additional animal experiments have suggested that growth hormone may generally act to shorten maximum lifespan; knockout mice lacking the receptor for growth hormone live especially long. Furthermore, mouse models lacking the insulin-like growth factor also live especially long and have low levels of growth hormone.]
 Insulin like growth factor (IGF-1) restriction
People suffering from a rare condition known as Laron syndrome have a mutation in the gene that makes the receptor for growth hormone. It is theorised that this mutation may hold a key to life extension.
Dr. Longo said that some level of IGF-1 was necessary to protect against heart disease, but that lowering the level might be beneficial. A drug that does this is already on the market for treatment of acromegaly, a thickening of the bones caused by excessive growth hormone. “Our underlying hypothesis is that this drug would prolong life span,” Dr. Longo said. He said he was not taking the drug, called pegvisomant or Somavert, which is very hard to obtain.
 Scientific controversy regarding anti-aging nutritional supplementation and medicine
Some critics dispute the portrayal of aging as a disease. For example, Leonard Hayflick, who determined that fibroblasts are limited to around 50 cell divisions, reasons that aging is an unavoidable consequence of entropy. Hayflick and fellow biogerontologists Jay Olshansky and Bruce Carnes have strongly criticized the anti-aging industry in response to what they see as unscrupulous profiteering from the sale of unproven anti-aging supplements.
 Ethics and politics of anti-aging nutritional supplementation and medicine
Politics relevant to the substances of life extension pertain mostly to communications and availability.
In the United States, product claims on food and drug labels are strictly regulated. The First Amendment (freedom of speech) protects third-party publishers’ rights to distribute fact, opinion and speculation on life extension practices. Manufacturers and suppliers also provide informational publications, but because they market the substances, they are subject to monitoring and enforcement by the Federal Trade Commission (FTC), which polices claims by marketers. What constitutes the difference between truthful and false claims is hotly debated and is a central controversy in this arena.
 Consumer motivations for using anti-aging products
Research by Sobh and Martin (2011) suggests that people buy anti-aging products to obtain a hoped-for self (e.g., keeping a youthful skin) or to avoid a feared-self (e.g., looking old). The research shows that when consumers pursue a hoped-for self, it is expectations of success that most strongly drive their motivation to use the product. The research also shows why doing badly when trying to avoid a feared self is more motivating than doing well. Interestingly, when product use is seen to fail it is more motivating than success when consumers seek to avoid a feared-self.
 Proposed strategies of life extension
Future advances in nanomedicine could give rise to life extension through the repair of many processes thought to be responsible for aging. K. Eric Drexler, one of the founders of nanotechnology, postulated cell repair machines, including ones operating within cells and utilizing as yet hypothetical molecular computers, in his 1986 book Engines of Creation. Raymond Kurzweil, a futurist and transhumanist, stated in his book The Singularity Is Near that he believes that advanced medical nanorobotics could completely remedy the effects of aging by 2030.
 Cloning and body part replacement
Some life extensionists suggest that therapeutic cloning and stem cell research could one day provide a way to generate cells, body parts, or even entire bodies (generally referred to as reproductive cloning) that would be genetically identical to a prospective patient. Recently, the US Department of Defense initiated a program to research the possibility of growing human body parts on mice. Complex biological structures, such as mammalian joints and limbs, have not yet been replicated. Dog and primate brain transplantation experiments were conducted in the mid-20th century but failed due to rejection and the inability to restore nerve connections. As of 2006, the implantation of bio-engineered bladders grown from patients’ own cells has proven to be a viable treatment for bladder disease. Proponents of body part replacement and cloning contend that the required biotechnologies are likely to appear earlier than other life-extension technologies.
The use of human stem cells, particularly embryonic stem cells, is controversial. Opponents’ objections generally are based on interpretations of religious teachings or ethical considerations. Proponents of stem cell research point out that cells are routinely formed and destroyed in a variety of contexts. Use of stem cells taken from the umbilical cord or parts of the adult body may not provoke controversy.
The controversies over cloning are similar, except general public opinion in most countries stands in opposition to reproductive cloning. Some proponents of therapeutic cloning predict the production of whole bodies, lacking consciousness, for eventual brain transplantation.
Main article: Cryonics
For cryonicists (advocates of cryopreservation), storing the body at low temperatures after death may provide an “ambulance” into a future in which advanced medical technologies may allow resuscitation and repair. They speculate cryogenic temperatures will minimize changes in biological tissue for many years, giving the medical community ample time to cure all disease, rejuvenate the aged and repair any damage that is caused by the cryopreservation process.
Many cryonicists do not believe that legal death is “real death” because stoppage of heartbeat and breathing—the usual medical criteria for legal death—occur before biological death of cells and tissues of the body. Even at room temperature, cells may take hours to die and days to decompose. Although neurological damage occurs within 4–6 minutes of cardiac arrest, the irreversible neurodegenerative processes do not manifest for hours. Cryonicists state that rapid cooling and cardio-pulmonary support applied immediately after certification of death can preserve cells and tissues for long-term preservation at cryogenic temperatures. People, particularly children, have survived up to an hour without heartbeat after submersion in ice water. In one case, full recovery was reported after 45 minutes underwater. To facilitate rapid preservation of cells and tissue, cryonics “standby teams” are available to wait by the bedside of patients who are to be cryopreserved to apply cooling and cardio-pulmonary support as soon as possible after declaration of death.
No mammal has been successfully cryopreserved and brought back to life, and resuscitation from cryonics is not possible with current science. Some scientists still support the idea based on their expectations of the capabilities of future science.
 Strategies for Engineered Negligible Senescence (SENS)
Main article: Strategies for Engineered Negligible Senescence
Another proposed life extension technology would combine existing and predicted future biochemical and genetic techniques. SENS proposes that rejuvenation may be obtained by removing aging damage via the use of stem cells and tissue engineering, removal of telomere-lengthening machinery, allotopic expression of mitochondrial proteins, targeted ablation of cells, immunotherapeutic clearance, and novel lysosomal hydrolases.
While many biogerontologists find these ideas “worthy of discussion” and SENS conferences feature important research in the field, some contend that the alleged benefits are too speculative given the current state of technology, referring to it as “fantasy rather than science”.
 Genetic modification
Gene therapy, in which artificial genes are integrated with an organism to replace mutated or otherwise deficient genes, has been proposed as a future strategy to prevent aging. Targeting catalase to the mitochondria resulted in a 20% lifespan increase in transgenic mice, and improved performance in AAV therapeutically infected mice. In 2012, Israeli researchers from Bar-Ilan University exhibited an increase in lifespan of male mice by over-expression of the SIRT6 gene. In these transgenic mice, levels of proteins involved in the ‘insulin-like growth factor 1 (IGF-1)’ pathway, which has been previously linked to longevity, were affected by SIRT6 expression.
 Fooling genes
In The Selfish Gene, Richard Dawkins describes an approach to life-extension that involves “fooling genes” into thinking the body is young. Dawkins attributes inspiration for this idea to Peter Medawar. The basic idea is that our bodies are composed of genes that activate throughout our lifetimes, some when we are young, and others when we are older. Presumably, these genes are activated by environmental factors, and the changes caused by these genes activating can be lethal. It is a statistical certainty that we possess more lethal genes that activate in later life than in early life. Therefore, to extend life, we should be able to prevent these genes from switching on, and we should be able to do so by “identifying changes in the internal chemical environment of a body that take place during aging… and by simulating the superficial chemical properties of a young body”.
 Reversal of informational entropy
According to some lines of thinking, the ageing process is routed into a basic reduction of biological complexity, and thus loss of information. In order to reverse this loss, gerontologist Marios Kyriazis suggested that it is necessary to increase input of actionable and meaningful information both individually (into individual brains), and collectively (into societal systems). This technique enhances overall biological function through up-regulation of immune, hormonal, antioxidant and other parameters, resulting in improved age-repair mechanisms. Working in parallel with natural evolutionary mechanisms that can facilitate survival through increased fitness, Kyriazis claims that the technique may lead to a reduction of the rate of death as a function of age, i.e. indefinite lifespan.
 History of life extension and the life extension movement
In 1970, the American Aging Association was formed under the impetus of Denham Harman, originator of the free radical theory of aging. Harman wanted an organization of biogerontologists that was devoted to research and to the sharing of information among scientists interested in extending human lifespan.
In 1976, futurists Joel Kurtzman and Philip Gordon wrote No More Dying. The Conquest Of Aging And The Extension Of Human Life, (ISBN 0-440-36247-4) the first popular book on research to extend human lifespan. Subsequently, Kurtzman was invited to testify before the House Select Committee on Aging, chaired by Claude Pepper of Florida, to discuss the impact of life extension on the Social Security system.
Saul Kent published The Life Extension Revolution (ISBN 0-688-03580-9) in 1980 and created a nutraceutical firm called the Life Extension Foundation, a non-profit organization that promotes dietary supplements. The Life Extension Foundation publishes a periodical called Life Extension Magazine. The 1982 bestselling book Life Extension: A Practical Scientific Approach (ISBN 0-446-51229-X) by Durk Pearson and Sandy Shaw further popularized the phrase “life extension”.
In 1983, Roy Walford, a life-extensionist and gerontologist, published a popular book called Maximum Lifespan. In 1988, Walford and his student Richard Weindruch summarized their research into the ability of calorie restriction to extend the lifespan of rodents in The Retardation of Aging and Disease by Dietary Restriction (ISBN 0-398-05496-7). It had been known since the work of Clive McCay in the 1930s that calorie restriction can extend the maximum lifespan of rodents. But it was the work of Walford and Weindruch that gave detailed scientific grounding to that knowledge. Walford’s personal interest in life extension motivated his scientific work and he practiced calorie restriction himself. Walford died at the age of 80 from complications caused by amyotrophic lateral sclerosis.
Money generated by the non-profit Life Extension Foundation allowed Saul Kent to finance the Alcor Life Extension Foundation, the world’s largest cryonics organization. The cryonics movement had been launched in 1962 by Robert Ettinger’s book, The Prospect of Immortality. In the 1960s, Saul Kent had been a co-founder of the Cryonics Society of New York. Alcor gained national prominence when baseball star Ted Williams was cryonically preserved by Alcor in 2002 and a family dispute arose as to whether Williams had really wanted to be cryopreserved.
Regulatory and legal struggles between the Food and Drug Administration (FDA) and the Life Extension Foundation included seizure of merchandise and court action. In 1991, Saul Kent and Bill Faloon, the principals of the Foundation, were jailed. The LEF accused the FDA of perpetrating a “Holocaust” and “seeking gestapo-like power” through its regulation of drugs and marketing claims.
In 1992, the American Academy of Anti-Aging Medicine (A4M) was formed to create what it considered an anti-aging medical specialty distinct from geriatrics, and to hold trade shows for physicians interested in anti-aging medicine. The American Board of Medical Specialties recognizes neither anti-aging medicine nor the A4M’s professional standing.
 Ethics and politics of life extension
Though many of scientists state that life extension and radical life extension are possible, there are still no international or national programs focused on radical life extension. There are political forces staying for and against life extension. In 2012 in Russia, and then in USA, Israel and Netherlands the Longevity political parties started. They aimed to provide political support to radical life extension research and technologies and ensure fastest possible and at the same time soft transition society to the next step – life without aging and with radical life extension and provide such the access to such technologies to the most of the currently living people. 
Leon Kass (chairman of the US President’s Council on Bioethics from 2001 to 2005) has questioned whether potential exacerbation of overpopulation problems would make life extension unethical. He states his opposition to life extension with the words:
“simply to covet a prolonged life span for ourselves is both a sign and a cause of our failure to open ourselves to procreation and to any higher purpose … [The] desire to prolong youthfulness is not only a childish desire to eat one’s life and keep it; it is also an expression of a childish and narcissistic wish incompatible with devotion to posterity.”
John Harris, former editor-in-chief of the Journal of Medical Ethics, argues that as long as life is worth living, according to the person himself, we have a powerful moral imperative to save the life and thus to develop and offer life extension therapies to those who want them.
Transhumanist philosopher Nick Bostrom has argued that any technological advances in life extension must be equitably distributed and not restricted to a privileged few. In an extended metaphor entitled “The Fable of the Dragon-Tyrant”, Bostrom envisions death as a monstrous dragon who demands human sacrifices. In the fable, after a lengthy debate between those who believe the dragon is a fact of life and those who believe the dragon can and should be destroyed, the dragon is finally killed. Bostrom argues that political inaction allowed many preventable human deaths to occur.
 Aging as a disease
Most mainstream medical organizations and practitioners do not consider aging to be a disease. David Sinclair says: “I don’t see aging as a disease, but as a collection of quite predictable diseases caused by the deterioration of the body”. The two main arguments used are that aging is both inevitable and universal while diseases are not. However not everyone agrees. Harry R. Moody, Director of Academic Affairs for AARP, notes that what is normal and what is disease strongly depends on a historical context. David Gems, Assistant Director of the Institute of Healthy Ageing, strongly argues that aging should be viewed as a disease. In response to the universality of aging, David Gems notes that it is as misleading as arguing that Basenji are not dogs because they do not bark. Because of the universality of aging he calls it a ‘special sort of disease’. Robert M. Perlman, coined the terms ‘aging syndrome’ and ‘disease complex’ in 1954 to describe aging.
The discussion whether aging should be viewed as a disease or not has important implications. It would stimulate pharmaceutical companies to develop life extension therapies and in the United States of America, it would also increase the regulation of the anti-aging market by the FDA. Anti-aging now falls under the regulations for cosmetic medicine which are less tight than those for drugs.
 See also
Main articles: List of life extension topics and Index of life extension-related articles
Advanced glycation end product
Aging movement control
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 Further reading
Biological Aging Measurement. Clinical Applications. Ward Dean, MD. The Center for Bio-Gerontology. 1988. Paperback, 426 pp. ISBN 0-937777-00-5
The Biology of Life Span: A Quantitative Approach. Leonid A. Gavrilov & Natalia S. Gavrilova (1991), New York: Harwood Academic Publisher, ISBN 3-7186-4983-7
Brain Boosters. Foods And Drugs That Make You Smarter. (A quote from the book: “It’s hard to distinguish between the health and anti-aging uses of the smart drugs and nutrients.”) Beverly Potter & Sebastian Orfali. Ronin Publishing. 1993. Paperback, 257 pages. ISBN 0-914171-65-8
Brain Fitness. Anti-Aging Strategies To Fight Alzheimer’s Disease, Supercharge Your Memory, Sharpen Your Intelligence, De-Stress Your Mind, Control Mood Swings, and Much More… Robert Goldman, MD, DO, PhD, With Ronald Klatz, MD, DO, and Liza Berger. Doubleday. 1995. Paperpack, 346 pp. ISBN 0-385-48869-6
The Directory of Life Extension Supplements. Life Extension Foundation. Published annually.
Fantastic Voyage: The Science Behind Radical Life Extension Raymond Kurzweil and Terry Grossman, MD. Rodale. 2004. 452 pp. ISBN 1-57954-954-3
50 Simple Ways To Live A Longer Life: Everyday Techniques From The Forefront Of Science. Suzanne Bohan and Glenn Thompson. Sourcebooks. 2005. Paperback, 287 pages. ISBN 1-4022-0375-6
Formula for Life. The Definitive Book on Correct Nutrition, Anti-Oxidants and Vitamins, Disease Prevention, and Longevity. Eberhard Kronhausen, EdD, and Phyllis Kronhausen EdD, with Harry B. Demopoulos, MD. William Morrow and Company. 1989. Paperback, 622 pages. ISBN 0-688-09426-0
How To Live Longer And Feel Better. Linus Pauling. W.H. Freeman and Company. 1986. Paperback, 413 pages. ISBN 0-380-70289-4
Life Extension. A Practical Scientific Approach. Adding Years to Your Life and Life to Your Years. Durk Pearson and Sandy Shaw. Warner Books. 1982. Hardcover, 858 pp. ISBN 0-446-51229-X
The Life Extension Companion. The Latest Breakthroughs in Health Science. Durk Pearson and Sandy Shaw. Warner Books. 1984. Hardcover, 430 pages. ISBN 0-446-51277-X
The Life Extension Revolution: The Definitive Guide to Better Health, Longer Life, and Physical Immortality. Saul Kent. 1980. Hard Cover. ISBN 0-688-03580-9
The Life Extension Revolution: The New Science of Growing Older Without Aging. Philip Lee Miller and Monica Reinagel. Bantam. 2005. Hardcover, (416 pages). ISBN 0-553-80353-0
The Life Extension Weight Loss Programme. Durk Pearson and Sandy Shaw.
LifeSpan-Plus. 900 Natural Techniques To Live Longer. Rejuvenate Your Heart; Stay Infection-Free; Prevent a Stroke; Reduce Stress; Control Your Blood Pressure; Strengthen Your Bones; Eliminate Body Toxins. By the editors of Prevention Magazine. Rodale. 1990. Hardcover, 422 pages. ISBN 0-87857-908-7
Live Longer Now. The First One Hundred Years Of Your Life. Jon N. Leanard, Jack L. Hofer, and Nathan Pritikin. Grosset and Dunlap. 1974 (predates the life extension movement, and therefore lacks megadosing recommendations.) Paperpack, 232 pages. ISBN 0-441-48514-6
The Long Tomorrow. Michael Rose. Oxford University Press. 2005. ISBN 0-19-517939-0
Merchants of Immortality. Chasing The Dream Of Human Life Extension. Stephen S. Hall. Houghton Mifflin Company. 2003. Paperback, 439 pp. ISBN 0-618-49221-6
Mind Food and Smart Pills. How To Increase Your Intelligence and Prevent Brain Aging. Ross Pelton. 1986. Paperback, 170 pp. ISBN 0-936809-00-0
No More Dying. The Conquest Of Aging And The Extension Of Human Life. Joel Kurtzman and Phillip Gordon. Dell. 1976. Paperpback, 252 pages. ISBN 0-440-36247-4
Prevention’s The Sugar Solution. Edited by Sari Harrar, Prevention Health News Editor. Rodale. 2005. Hardcover, 406 pages. ISBN 1-57954-912-8
Secrets of Life Extension. How to halt or reverse the aging process and live a long and healthy life. You can extend the rest of your life. All the new scientific breakthroughs John A. Mann. Bantam Books. 1980. Paperback, 296 pages. ISBN 0-553-23450-1
Nutrition Against Disease. Dr. Roger J. Williams. Pitman Publishing Corporation. 1971 (predates megadosing). 370 pages. ISBN 0-273-31850-0
Smart Drugs & Nutrients. How To Improve Your Membory And Increase Your Intelligence Using The Latest Discoveries In Neuroscience. (Many of the substances in this book have life-extending or cell regenerating effects.) Ward Dean, MD and Joh Morgenthaler. B&J Publications. 1990. Paperback, 222 pp. ISBN 0-9627418-9-2
Smart Drugs II: The Next Generation: New Drugs and Nutrients to Improve Your Memory and Increase Your Intelligence. Ward Dean (MD), John Morgenthaler, Steven Wm Fowkes. Smart Publications. 1993. Paperback, 287 pages. ISBN 0-9627418-7-6
Stop Aging Now! The Ultimate Plan For Staying Young & Reversing The Aging Process. Based On Cutting-Edge Research Revealing The Amazing Anti-aging Powers Of Supplements, Herbs, & Food. Jean Carper. Harper Perennial. 1995. Paperback, 372 pp. ISBN 0-06-098500-3
Stop the FDA. Save Your Health Freedom. Articles by Linus Pauling, PhD; Abram Hoffer, MD; Ward Dean, MD; Senator Orrin Hatch; Durk Pearson and Sandy Shaw; and many more. (Many essays on health politics, by various leaders of the Life Extension Movement). Edited by John Morgenthaler & Steven Wm. Fowkes. Health Freedom Publications. 1992. Paperback, 186 pp. ISBN 0-9627418-8-4
The Wrinkle Cure. The All-Natural Formula for Stopping Time. Unlock the Power of Cosmeceuticals for Supple, Youthful Skin. Nicholas Perricone, MD. Rodale. 2000. Hardcover, 208 pages. ISBN 1-57954-237-9
Your Personal Life-Extension Program. A Practical Guide to the New Science That Can Make You Stronger, Smarter, Sexier, More Energetic, and More Youthful. Saul Kent. Morrow. 1985. Hardcover, 384 pages. ISBN 0-688-00629-9
 Scientific journals
Holzenberger M, Dupont J, Ducos B, et al. (January 2003). “IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice”. Nature 421 (6919): 182–7. doi:10.1038/nature01298. PMID 12483226.
http://www.dovepress.com/clinical-interventions-in-aging-journal Clinical Interventions in Aging Editor-in-Chief: Dr Richard F Walker. Publisher: Dove Medical Press Ltd. ISSN 1176-9092. Published Quarterly
Rejuvenation Research Editor: Aubrey de Grey. Publisher: Mary Ann Liebert, Inc. ISSN 1549-1684 – Published Quarterly
 External links
Aubrey de Grey: ‘We will be able to live to 1,000′
Kurzweil Biomed/Life Extension News
Vitae Institute non-profit for developing life-extension technology through basic research
The British Longevity Society
This article uses bare URLs for citations. Please consider adding full citations so that the article remains verifiable. Several templates and the Reflinks tool are available to assist in formatting. (Reflinks documentation) (April 2012)
Calorie restriction ·
Free-radical theory ·
Gene therapy ·
Indefinite lifespan ·
Index of topics related to life extension ·
Mind uploading ·
Printable organs ·
Stem-cell therapy ·
Strategies for Engineered Negligible Senescence ·
Bill Andrews ·
Aubrey de Grey ·
Terry Grossman ·
Leonard Hayflick ·
Denham Harman ·
Saul Kent ·
Ray Kurzweil ·
Marios Kyriazis ·
Durk Pearson ·
Sandy Shaw ·
Roy Walford ·
Michael D. West ·
Alcor Life Extension Foundation ·
Alliance for Aging Research ·
American Academy of Anti-Aging Medicine ·
American Aging Association ·
American Cryonics Society ·
Cryonics Institute ·
Immortalist Society ·
Immortality Institute ·
Life Extension Foundation ·
Methuselah Foundation ·
SENS Research Foundation ·
Sierra Sciences ·
Society for Venturism
Life Extension (1982) ·
The First Immortal (1998) ·
Fantastic Voyage (2004) ·
Ending Aging (2007) ·
Transcend: Nine Steps to Living Well Forever (2009)
Maximum life span ·
Life extension ·
Life expectancy ·
Immortality (Biological immortality ·
Eternal youth ·
Alleged Brazilian supercentenarians ·
Longevity claims ·
Incomplete longevity claims ·
Longevity myths ·
People reported to have lived beyond 130
Oldest people ·
Oldest people by year of birth ·
100 verified oldest people (males ·
Oldest people by nation ·
Oldest living people by nation ·
Longest marriages ·
Activists, non-profit leaders, and philanthropists ·
Actors, filmmakers, and entertainers ·
Authors, poets, and journalists ·
Educators, school administrators, social scientists, and linguists ·
Jurists and practitioners of law ·
Medical professionals ·
Military commanders ·
Musicians, composers, and music patrons ·
Philosophers and theologians ·
Politicians and government servants ·
Religious figures ·
Royalty and nobility ·
Scientists and mathematicians ·
Deaths by year (before 1980 ·
By continent (Europe) By country (Australia ·
Puerto Rico ·
United Kingdom ·
List of last surviving veterans of military insurgencies and wars (European ·
Last surviving World War I veterans by country ·
Surviving veterans of the Spanish Civil War ·
Living recipients of the Knight’s Cross ·
Last survivors of historic events
Long-living organisms ·
List of oldest trees ·
List of oldest dogs
See also: Gerontology · Ageing · Biodemography of human longevity · Senescence · Life extension-related topics · Extreme longevity tracking · FOXO3 longevity gene · Immortality in fiction
[Visualization of the age-related changes in expressions of DNA methyltransferases in mouse oocytes using two-photon imaging system].
[Article in Chinese]
Tian N, Zhang L, Zheng JH, Li Y, Ma WY.
State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, China. firstname.lastname@example.org
Quantum dot (QD) is widely used as fluorescent labeling dye for its strong anti-fluorescence quenching, high quantum yield, wide absorption spectra, and narrow emission spectra. In the present paper, QD 585-labeled DNA methyltransferases (Dnmts) and Hoechst 33342-labeled chromosomes were imaged simultaneously using two-photon imaging system. The authors’ results showed that aging mouse oocytes may be not suitable for in-vitro maturation: both the localizations and expression levels of Dnmts in in-vitro matured oocytes of aging mice were changed, and these changes may be related to the abnormal DNA methylation modification.
PMID: 23427529 [PubMed – in process]
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Destroy user interface controlPublication Types
Modality-specific changes in P300 parameters in patients with dementia of the Alzheimer type.
Pokryszko-Dragan A, Słotwiński K, Podemski R
Department of Neurology, Medical University, Wrocław, Poland. A-Z@pharmanet.com.pl
BACKGROUND: The relationship between the parameters of the P300 potential and the degree or profile of cognitive decline remains controversial. The aim of our study was to evaluate parameters of auditory and visual P300 in patients with mild and moderate dementia of the Alzheimer type (DAT) and to correlate these with neuropsychological test results. MATERIAL/METHODS: The study group comprised 13 patients with DAT and 13 healthy, age-matched controls. Auditory and visual event-related potentials were evoked using a basic oddball paradigm. P300 latency and amplitude were compared in patients with DAT and controls and between subgroups of patients with mild and moderate DAT. Correlations between P300 parameters and the results of the Mini-Mental State Examination (MMSE), the Global Deterioration Score (GDS), and the Alzheimer’s Disease Assessment Scale (ADAS-cog) were also analyzed. RESULTS: The mean latency of auditory P300 was significantly prolonged, and the mean amplitude of visual P300 was significantly lower in the DAT patients. 4 patients with DAT (31%) had a prolonged latency of auditory P300. No significant differences in P300 parameters were found between mildly demented and controls or between mildly and moderately demented. A positive correlation was found between MMSE score and auditory P300 latency in Fz and visual P300 amplitude in Cz. CONCLUSIONS: P300 parameters undergo significant, modality-specific changes in patients with DAT. However, they are not sensitive enough to differentiate early dementia from normal aging.
Med. Sci. Monit. (2003)
The honor roll:
1.Massachusetts General Hospital, Boston
2.Johns Hopkins Hospital, Baltimore
3.Mayo Clinic, Rochester, Minn.
5.Ronald Reagan UCLA Medical Center, Los Angeles
6.Barnes-Jewish Hospital/Washington University, St. Louis
7.New York Presbyterian University Hospital of Columbia and Cornell, N.Y.
8.Duke University Medical Center, Durham, N.C.
9.Brigham and Women’s Hospital, Boston
10.UMPC University of Pittsburgh Medical Center
11.NYU Langone Medical Center, New York
12.Northwestern Memorial Hospital, Chicago
13.UCSF Medical Center, San Francisco
14.Mount Sinai Medical Center, New York
15.Hospital of the University of Pennsylvania, Philadelphia
16.Indiana University Health, Indianapolis
17.University of Michigan Hospitals and Health Centers, Ann Arbor
The ratings also listed the best hospitals for major medical specialties. The winners in each category:
■Cancer: University of Texas M.D. Anderson Cancer Center, Houston
■Cardiology and Heart Surgery: Cleveland Clinic
■Diabetes and Endocrinology: Mayo Clinic
■Ear, Nose, and Throat: Johns Hopkins Hospital
■Gastroenterology: Mayo Clinic
■Geriatrics: Johns Hopkins Hospital
■Gynecology: Mayo Clinic
■Nephrology: Cleveland Clinic
■Neurology and Neurosurgery: Johns Hopkins Hospital
■Ophthalmology: Bascom Palmer Eye Institute at the University of Miami
■Orthopedics: Hospital for Special Surgery, New York
■Psychiatry: Johns Hopkins Hospital
■Pulmonology: National Jewish Health, Denver-University of Colorado Hospital
■Rehabilitation: Rehabilitation Institute of Chicago
■Rheumatology: Johns Hopkins Hospital
■Urology: Cleveland Clinic
…more at: http://www.webmd.com/news/20120717/mass-general-tops-list-of-best-us-hospitals
Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents
M A Lane,
D J Baer,
W V Rumpler,
D K Ingram,
E M Tilmont,
R G Cutler, and
G S Roth
Many studies of caloric restriction (CR) in rodents and lower animals indicate that this nutritional manipulation retards aging processes, as evidenced by increased longevity, reduced pathology, and maintenance of physiological function in a more youthful state. The anti-aging effects of CR are believed to relate, at least in part, to changes in energy metabolism. We are attempting to determine whether similar effects occur in response to CR in nonhuman primates. Core (rectal) body temperature decreased progressively with age from 2 to 30 years in rhesus monkeys fed ad lib (controls) and is reduced by approximately 0.5 degrees C in age-matched monkeys subjected to 6 years of a 30% reduction in caloric intake. A short-term (1 month) 30% restriction of 2.5-year-old monkeys lowered subcutaneous body temperature by 1.0 degrees C. Indirect calorimetry showed that 24-hr energy expenditure was reduced by approximately 24% during short-term CR. The temporal association between reduced body temperature and energy expenditure suggests that reductions in body temperature relate to the induction of an energy conservation mechanism during CR. These reductions in body temperature and energy expenditure are consistent with findings in rodent studies in which aging rate was retarded by CR, now strengthening the possibility that CR may exert beneficial effects in primates analogous to those observed in rodents.
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