Oral Cancer Prevention (PDQ®)
Last Modified: 01/09/2013
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What is prevention? click to expand contents
General Information About Oral Cancer click to collapse contents
Oral cancer is a disease in which malignant (cancer) cells form in the lips, mouth, or throat.
Oral cancer may form in any of three main areas:
Oral cavity, which includes:
The front two thirds of the tongue.
The gingiva (gums).
The buccal mucosa (the lining of the inside of the cheeks).
The floor (bottom) of the mouth under the tongue.
The hard palate (the front, bony part of the roof of the mouth).
The retromolar trigone (the small area behind the wisdom teeth).
Anatomy of the oral cavity. The oral cavity includes the lips, hard palate (the bony front portion of the roof of the mouth), soft palate (the muscular back portion of the roof of the mouth), retromolar trigone (the area behind the wisdom teeth), front two-thirds of the tongue, gingiva (gums), buccal mucosa (the inner lining of the lips and cheeks), and floor of the mouth under the tongue.
Oropharynx, which includes:
The middle part of the pharynx (throat) behind the mouth.
The back third of the tongue.
The soft palate (the back, soft part of the roof of the mouth).
The side and back walls of the throat.
Most oral cancers start in squamous cells (thin, flat cells) that line the lips, oral cavity, and oropharynx. Cancer that forms in squamous cells is called squamous cell carcinoma. Squamous cell carcinoma can form from lesions on the mucous membranes (the lining of the mouth and throat). These lesions include leukoplakia (an abnormal white patch of cells) and erythroplakia (an abnormal red patch of cells).
In Western countries, such as the United States, the most common areas for oral cancer are the tongue and the floor of the mouth.
Oral cancer is more common in men than in women.
. Men are more than twice as likely as women to have oral cancer and die from it.
Oral Cancer Prevention click to collapse contents
Avoiding risk factors and increasing protective factors may help prevent cancer.
Avoiding cancer risk factors may help prevent certain cancers. Risk factors include smoking, being overweight, and not getting enough exercise. Increasing protective factors such as quitting smoking, eating a healthy diet, and exercising may also help prevent some cancers. Talk to your doctor or other health care professional about how you might lower your risk of cancer.
The following are risk factors for oral cancer:
Using tobacco is the leading cause of oral cancer.
All forms of tobacco, including cigarettes, pipes, cigars, and chewing (smokeless) tobacco, can cause oral cancer. For cigarette smokers, the risk of oral cancer increases with the number of cigarettes smoked per day. Tobacco use is most likely to cause oral cancer in the floor of the mouth, but also causes cancer in other parts of mouth and throat.
The risk of oral cancer is greater in people who use both tobacco and alcohol than it is in people who use only tobacco or only alcohol.
Tobacco users who have had oral cancer may develop second cancers in the oral cavity or nearby areas. These areas include the nose, throat, vocal cords, esophagus, and trachea (windpipe). This is because the oral cavity and nearby areas have been exposed to the harmful substances in tobacco, and new cancers may form over time.
Using alcohol is a major risk factor for oral cancer.
The risk of oral cancer increases with the number of alcoholic drinks consumed per day. The risk of oral cancer is about twice as high in people who have 3 to 4 alcoholic drinks per day compared to those who don’t drink alcohol.
The risk of oral cancer is higher in people who use both alcohol and tobacco than it is in people who use only alcohol or only tobacco.
Being infected with a certain type of HPV virus, especially HPV type 16, increases the risk of oral cancer. HPV infection is spread mainly through sexual contact. People who have many oral sex partners have a higher risk of HPV infection. The number of cases of oral cancer caused by HPV infection is small but increasing.
Being exposed to sunlight may increase the risk of lip cancer. Lip cancer occurs most often on the lower lip.
The following is a protective factor for oral cancer:
Studies have shown that when people stop smoking cigarettes, their risk of oral cancer decreases by one-half (50%) within 5 years. Within 10 years of quitting, their risk of oral cancer is the same as for a person who never smoked cigarettes.
It is not clear whether avoiding certain risk factors will decrease the risk of oral cancer.
Certain risk factors, such as drinking alcohol, HPV infection, and sun exposure, increase the risk of oral cancer. It may seem that by avoiding these risk factors, the chance of having oral cancer would decrease, but that has not been proven.
Cancer prevention clinical trials are used to study ways to prevent cancer.
Cancer prevention clinical trials are used to study ways to lower the risk of certain types of cancer. Some cancer prevention trials are done with healthy people who have not had cancer but who have an increased risk for cancer. Other prevention trials are done with people who have had cancer and are trying to prevent another cancer of the same type or to lower their chance of developing a new type of cancer. Other trials are done with healthy volunteers who are not known to have any risk factors for cancer.
The purpose of some cancer prevention clinical trials is to find out whether actions people take can prevent cancer. These may include eating fruits and vegetables, exercising, quitting smoking, or taking certain medicines, vitamins, minerals, or food supplements.