IHOP congenital kidney disease chemists

KIBRA and CLSTN2 polymorphisms exert interactive effects on human episodic memory.

Preuschhof C, Heekeren HR, Li SC, Sander T, Lindenberger U, Bäckman L
Max Planck Institute for Human Development, Berlin, Germany. preuschhof@mpib-berlin.mpg.de

Individual differences in episodic memory are highly heritable. Several studies have linked a polymorphism in the gene encoding the KIBRA protein to episodic memory performance. Results regarding CLSTN2, the gene encoding the synaptic protein calsyntenin 2, have been less consistent, possibly pointing to interactions with other genes. Given that both KIBRA and CLSTN2 are expressed in the medial temporal lobe and have been linked to synaptic plasticity, we investigated whether KIBRA and CLSTN2 interactively modulate episodic memory performance (n=383). We replicated the beneficial effect of the KIBRA T [?]-allele on episodic memory, and discovered that this effect increases with the associative demands of the memory task. Importantly, the memory-enhancing effect of the KIBRA T [?]-allele was boosted by the presence of the CLSTN2 C-allele, which positively affected memory performance in some previous studies. In contrast, the presence of CLSTN2 C-allele led to reduced performance in subjects homozygous for the KIBRA C-allele. Overall, these findings suggest that KIBRA and CLSTN2 interactively modulate episodic memory performance, and underscore the need for delineating the interactive effects of multiple genes on brain and behavior.

Neuropsychologia (2010)
Adaptation of the genetics of memory for recall for the administration of the involuntary action of having to urinate frequent urination memory recall research into the configuration of the kinetics which makes a body function which makes the kidneys function to complete urinary function repetitively control mechanisms within the brain


About garyskeete

ASHWORTH MEDICINE-Professional Medical Assisting, Doctor of Science,Legal Assistant Diploma BSc Criminal Justice PhD Computational Neuroscience MD DSC Epigenetics
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