IHOP dementia and Alzheimer’s

Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 [?] suppresses efficiently tumour angiogenesis.

Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, Horii A, Tani K, Asano S, Nakamura Y, Matsuno S
First Department of Surgery, Tohoku University Medical School, 1-1 Seiryomachi, Aoba-ku, 980-8574 Sendai, Japan.

The brain-specific angiogenesis inhibitor 1 [?] gene has been isolated in an attempt to find fragments with p53 “functional” binding sites. As reported herein and by others, brain-specific angiogenesis inhibitor 1 [?] expression is present in some normal tissues, but is reduced or lost in tumour tissues. Such data and its particular structure prompted the hypothesis that brain-specific angiogenesis inhibitor 1 [?] may act as a mediator in the local angiogenesis balance. We herein demonstrate that brain-specific angiogenesis inhibitor 1 [?] over-expression suppresses tumour angiogenesis, delaying significantly the human tumour growth in immunodeficient mice. The inhibitory effect of brain-specific angiogenesis inhibitor 1 [?] was documented using our intravital microscopy system, strongly implicating brain-specific angiogenesis inhibitor 1 [?] as a mediator in the control of tumour angiogenesis. In contrast, in vitro tumour cell proliferation was not inhibited by brain-specific angiogenesis inhibitor 1 [?] transfection, whereas some level of cytotoxicity was assessed for endothelial cells. Immunohistochemical analysis of tumour samples confirmed a reduction in the microvessel density index in brain-specific angiogenesis inhibitor 1 [?]-overexpressing tumours. At messenger level, moderate changes could be detected, involving the down-regulation of vascular endothelial growth factor and collagenase-1 expression. Furthermore, brain-specific angiogenesis inhibitor 1 [?] expression that was lost in a selection of human cancer cell lines could be restored by wild-type p53 adenoviral transfection. Brain-specific angiogenesis inhibitor 1 [?] should be considered for gene therapy and development of efficient drugs based on endogenous antiangiogenic molecules.

Br. J. Cancer (2002)
Concepts With the advent of this the correlation to controls over brain systems over cancerous manifestations in Alzheimer’s over the effect of the cell lines being manipulated to form tumours and over the destruction and dissolvement of tissues be positive resources in collecting information for the repair synthesis reconstruction and reanimation of tissue the reconstruction regenerative biology and reinstatement of brain tissue activity and rehabilitation so the beginning of brain tissue regeneration brain tissue rebuilding repair a brain systems analysis and computation of calculus of abilities for  memory brain tissue reengineering the rebuilding of the brain itself in Vivo 3D printing and stem cells holographically the advent of usable tissue usable brain attributes of the scaffolds self-assembly be weighed tissue engineering itself and the ability to utilize it constructively not a band aid solution prevention of deterioration destruction of brain cells and tissue by systematic repair and regeneration by scaffolds and stem cells to reconstruct the brain memory cognition recall and complete rehabilitation in recovery


About garyskeete

ASHWORTH MEDICINE-Professional Medical Assisting, Doctor of Science,Legal Assistant Diploma BSc Criminal Justice PhD Computational Neuroscience MD DSC Epigenetics
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