Protein tyrosine [?] phosphatase receptor-type O (PTPRO) is co-regulated by E2F1 and miR-17-92.
Xu X, Hong Y, Kong C, Xu L, Tan J, Liang Q, Huang B, Lu J
Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China.
PTPRO is often silenced by DNA hypermethylation in primary human tumors and cancer cell lines and functions as a tumor suppressor. Here we show that PTPRO is a target of E2F1. In addition, the microRNA cluster miR-17-92, another target of E2F1, participates in PTPRO regulation. PTPRO mRNA was up-regulated during S phase [?] in synchronized HeLa cells and in vitro PTPRO promoter activity is high in early S phase [?] while the PTPRO 3’UTR reporter activity is low in late S phase [?]. This study provides evidence that the PTPRO gene is co-regulated by both E2F1 and miR-17-92.
FEBS Lett. (2008)
PMID: 18644370 Fulltext – Related articles – Download citation