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TSpace Repository School of Graduate Studies – Theses Master
Title:
Development of a Methodology for the Examination of Conductance Densities and Distributions of Hippocampal Oriens-lacunosum/moleculare Interneurons using Ensemble Modelling
Author:
Vladislav Sekulic
Advisor:
Frances Skinner
Department:
Physiology
Keywords:
computational; neuroscience
Issue Date:
27-Nov-2013
Abstract (summary):
The hippocampus is a brain region that is critically involved in memory formation. Stratum oriens-lacunosum/moleculare (O-LM) interneurons have been shown to modulate incoming sensory information onto principal cells in CA1. Multi-compartment computational models of O-LM cells have been developed to better understand their functional roles in network contexts. Due to the variability and incompleteness of experimental details, however, a population of models that collectively captures intrinsic O-LM cell behavior is needed. We generated a database of O-LM models with physiologically plausible ranges for conductance densities using NEURON simulations on a supercomputer cluster. A subset of models that best represented O-LM cell electrophysiological output was subsequently extracted from the database and analyzed in order to determine correlations in conductance densities. Three major co-regulatory balances were found, which provide specific hypotheses for experimental investigations and point to the possibility of identifying a “signature” of conductance density balances for particular neuronal cell types.
URI:
http://hdl.handle.net/1807/42913
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Permanent link

http://hdl.handle.net/1807/42913
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