The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.
McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD
Department of Molecular Biology, Princeton University, New Jersey 08544-1014, USA.
The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle progression in higher eukaryotes. This report describes the isolation of a novel, highly conserved 434 kDa protein, designated TRRAP, which interacts specifically with the c-Myc N terminus and has homology to the ATM/PI3-kinase family. TRRAP also interacts specifically with the E2F-1 transactivation domain. Expression of transdominant mutants of the TRRAPprotein or antisense RNA blocks c-Myc- and E1A-mediated oncogenic transformation. These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways.
PMID: 9708738 Fulltext – Related articles – Download citation