IHOP allergy and immunology pubmed

AbstractSend to:
Brain Res. 2015 Jul 30. pii: S0006-8993(15)00576-4. doi: 10.1016/j.brainres.2015.07.033. [Epub ahead of print]
Galectin-1 suppresses methamphetamine induced neuroinflammation in Human brain microvascular endothelial cells: Neuroprotective role in maintaining Blood brain barrier integrity.
Parikh N1, Aalinkeel R1, Reynolds JL1, Nair BB1, Sykes DE1, Mammen MJ1, Schwartz SA1, Mahajan SD2.
Author information
Methamphetamine (Meth) abuse can lead to the breakdown of the blood-brain-barrier (BBB) integrity leading to compromised CNS function. The role of Galectins in the angiogenesis process in tumor-associated endothelial cells (EC) is well established; however no data are available on the expression of Galectins in normal human brain microvascular endothelial cells and their potential role in maintaining BBB integrity. We evaluated the basal gene/protein expression levels of Galectin-1, -3 and -9 in normal primary human brain microvascular endothelial cells (BMVEC) that constitute the BBB and examined whether Meth altered Galectin expression in these cells, and if Galectin-1 treatment impacted the integrity of an in-vitro BBB. Our results showed that BMVEC expressed significantly higher levels of Galectin-1 as compared to Galectin-3 and -9. Meth treatment increased Galectin-1 expression in BMVEC. Meth induced decrease in TJ proteins ZO-1, Claudin-3 and adhesion molecule ICAM-1 was reversed by Galectin-1. Our data suggests that Galectin-1 is involved in BBB remodeling and can increase levels of TJ proteins ZO-1 and Claudin-3 and adhesion molecule ICAM-1 which helps maintain BBB tightness thus playing a neuroprotective role. Galectin-1 is thus an important regulator of immune balance from neurodegeneration to neuroprotection, which makes it an important therapeutic agent/ target in the treatment of drug addiction and other neurological conditions.
Copyright © 2015. Published by Elsevier B.V.
Blood Brain Barrier; Galectin-1; Human Brain Microvascular endothelial cells; Methamphetamine; Oxidative stress; Proinflammatory cytokines; Tight Junctions; Transendothelial electrical resistance
PMID: 26236024 [PubMed – as supplied by publisher]


About garyskeete

ASHWORTH MEDICINE-Professional Medical Assisting, Doctor of Science,Legal Assistant Diploma BSc Criminal Justice PhD Computational Neuroscience MD DSC Epigenetics
This entry was posted in Uncategorized. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s