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Bull World Health Organ. 2015 Jun 1;93(6):390-9. doi: 10.2471/BLT.14.147439. Epub 2015 Mar 30.
Tobacco smoking and tuberculosis treatment outcomes: a prospective cohort study in Georgia.
Gegia M1, Magee MJ2, Kempker RR3, Kalandadze I4, Chakhaia T1, Golub JE5, Blumberg HM3.
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Abstractin English, Arabic, Chinese, French, Russian, Spanish
OBJECTIVE:
To assess the effect of tobacco smoking on the outcome of tuberculosis treatment in Tbilisi, Georgia.
METHODS:
We conducted a prospective cohort study of adults with laboratory-confirmed tuberculosis from May 2011 to November 2013. History of tobacco smoking was collected using a standardized questionnaire adapted from the global adult tobacco survey. We considered tuberculosis therapy to have a poor outcome if participants defaulted, failed treatment or died. We used multivariable regressions to estimate the risk of a poor treatment outcome.
FINDINGS:
Of the 591 tuberculosis patients enrolled, 188 (31.8%) were past smokers and 271 (45.9%) were current smokers. Ninety (33.2%) of the current smokers and 24 (18.2%) of the participants who had never smoked had previously been treated for tuberculosis (P < 0.01). Treatment outcome data were available for 524 of the participants, of whom 128 (24.4%) – including 80 (32.9%) of the 243 current smokers and 21 (17.2%) of the 122 individuals who had never smoked – had a poor treatment outcome. Compared with those who had never smoked, current smokers had an increased risk of poor treatment outcome (adjusted relative risk, aRR: 1.70; 95% confidence interval, CI: 1.00-2.90). Those who had ceased smoking more than two months before enrolment did not have such an increased risk (aRR: 1.01; 95% CI: 0.51-1.99).
CONCLUSION:
There is a high prevalence of smoking among patients with tuberculosis in Georgia and smoking increases the risk of a poor treatment outcome.
PMID: 26240460 [PubMed – in process]
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About garyskeete

ASHWORTH MEDICINE-Professional Medical Assisting, Doctor of Science,Legal Assistant Diploma BSc Criminal Justice
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